Status:
RECRUITING
EyeConic: Qualification for Cone-Optogenetics
Lead Sponsor:
Institute of Molecular and Clinical Ophthalmology Basel
Conditions:
Retinal Dystrophies
Eligibility:
All Genders
Brief Summary
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed...
Detailed Description
In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them ...
Eligibility Criteria
Inclusion
- Inclusion Criteria (patients):
- Diagnosis of generalized IRD
- Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
- Availability of macular optical coherence tomography (OCT)
- Inclusion Criteria (controls):
- Normal ophthalmic findings
- Availability of macular optical coherence tomography (OCT)
- Exclusion Criteria (all):
- Other eye diseases with a significant effect on vision or retinal structure
- Extraocular disease affecting retinal structure such as neurodegenerative diseases
Exclusion
Key Trial Info
Start Date :
July 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT05294978
Start Date
July 1 2021
End Date
December 1 2026
Last Update
July 31 2025
Active Locations (9)
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1
University of California San Francisco, Department of Ophthalmology
San Francisco, California, United States, 94158
2
Bascom Palmer Eye Institute
Miami, Florida, United States, 33136
3
University of Pittsburgh, Department of Ophthalmology
Pittsburgh, Pennsylvania, United States, 15213
4
Beijing Institute of Ophthalmology
Beijing, China