Status:
COMPLETED
Fasting-Associated Immune-metabolic Remission of Diabetes
Lead Sponsor:
Charite University, Berlin, Germany
Conditions:
Type 2 Diabetes Mellitus
Obesity
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
People with a body mass index above 28 kg/m² and an onset of type 2 diabetes within the last 4 years had a remission (HbA1c \<6.5% without medication) of diabetes in over 80% upon weight loss of 15 kg...
Detailed Description
A remission of type 2 diabetes can be achieved in over 80% of people with a diagnosis within the last 4 years and overweight or obesity by weight loss of 15 kg. The mechanisms involve an improvement o...
Eligibility Criteria
Inclusion
- Type 2 diabetes diagnosed less than 4 or over 8 years, before study,
- BMI \> 28 kg/m²,
- willingness to follow weight loss diet,
Exclusion
- consuming disease,
- intolerance for very low calorie formula diet,
- known severe hepatic disease or liver cirrhosis,
- type 1 diabetes,
- severe disease of kidney or heart,
- advanced diabetic retinopathy,
- intake of glucocorticoids,
- drug or alcohol abuse,
- weight loss of \>5 kg in the last 3 month,
- eating disorder
Key Trial Info
Start Date :
September 25 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2023
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT05295160
Start Date
September 25 2020
End Date
April 30 2023
Last Update
August 30 2023
Active Locations (1)
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1
Charité Campus Benjamin Franklin
Berlin, Germany, 12203