Status:
RECRUITING
Hypercapnia in Orthostatic Hypotension
Lead Sponsor:
University of Calgary
Conditions:
Orthostatic Hypotension
Neurogenic Orthostatic Hypotension
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away fro...
Detailed Description
BACKGROUND: Regulation of tissue blood supply to vital organs such as the brain and heart is met in large part by local adjustment of the microvasculature (autoregulation) and autonomic nervous system...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Male and Female
- Non - smokers.
- Able and willing to provide informed consent.
- Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.
Exclusion
- Medical therapies or medications which could interfere with testing of autonomic function
- Participants with somatization or severe anxiety symptoms will be excluded
- Pregnant or breast-feeding females
- Inability to tolerate mask for the duration of the study
- Subjects who require portable oxygen at rest or with exercise
- Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
- Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These include: dementia, alcohol and/or drug abuse, cerebrovascular disease, kidney or liver disease, surgical procedures where the nerves of the sympathetic nervous system have been cut.
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.
Key Trial Info
Start Date :
March 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05295810
Start Date
March 1 2022
End Date
May 31 2027
Last Update
December 9 2024
Active Locations (1)
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1
University of Calgary
Calgary, Alberta, Canada