Status:
ACTIVE_NOT_RECRUITING
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
Lead Sponsor:
Columbia University
Collaborating Sponsors:
Alpha-1 Foundation
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Alpha 1-Antitrypsin Deficiency
Genetic Disease
Eligibility:
All Genders
18+ years
Brief Summary
Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. The purpose of this study is to examine the density of the lung as measured by chest computed tom...
Detailed Description
Progression of lung disease in patients with Alpha-1 Anti-trypsin deficiency is variable and while some patients may have stable lung function over many years, some progress and deteriorate rapidly. C...
Eligibility Criteria
Inclusion
- Males and females aged 18 years and older
- Patients with known Alpha-1 Anti-trypsin deficiency (PiZZ)
- Be an existing member of the Alpha-1 Foundation Clinical Cohort (Alpha-1 Foundation Research Registry)
- Willingness to perform study procedures of Chest CT, blood biomarker determination, questionnaire completion, and lung function testing.
Exclusion
- AATD non-PiZZ status, including carriers
- Pregnancy at the time of the screening visit
- COPD exacerbation or other pulmonary infection within 6 weeks of baseline visit
- Previous lung or liver transplantation or currently on the transplant list
Key Trial Info
Start Date :
March 23 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2027
Estimated Enrollment :
286 Patients enrolled
Trial Details
Trial ID
NCT05297812
Start Date
March 23 2022
End Date
January 1 2027
Last Update
December 13 2024
Active Locations (9)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
2
University of California - Los Angeles
Los Angeles, California, United States, 90095
3
National Jewish Health
Denver, Colorado, United States, 80206
4
University of Chicago
Chicago, Illinois, United States, 60637