Status:
UNKNOWN
The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment
Lead Sponsor:
Fatima College of Health Sciences
Collaborating Sponsors:
ART Fertility Clinics LLC
Conditions:
Poor Response to Ovulation Induction
PCOS
Eligibility:
FEMALE
18-45 years
Brief Summary
According the World Health Organization (WHO), infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unpro...
Detailed Description
Infertility affects approximately 1 in every 4 couples and the WHO (World Health Organization) has defined infertility as a "disease" (World Health Organization (WHO). International Classification of ...
Eligibility Criteria
Inclusion
- depending on the ART Fertility Clinic patients, we are intending to include:
- Women diagnosed with infertility (when pregnancy is not achieved after 1 year of having regular sexual intercourse without birth control for those under 35 years of age or if pregnancy is not achieved after 6 months of trying to conceive naturally for those older than 35 years of age). Further on, women with proven tubal factor infertility or couples with infertility as a result of a male factor, without the previously mentioned time of not achieving a pregnancy.
- Women undergoing or in the way to undergo IVF and classified as poor responders according to the four groups of the POSEIDON criteria (Conforti et al., 2019), including patients with a previous oral contraceptive intake.
- Women diagnosed with PCOS based on the Rotterdam criteria (Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, 2004.
- Women diagnosed with endometriosis confirmed by Laparoscopy or visible endometrioma without being diagnosed by laparoscopy (If possible to be enrolled in the research).
- Women planned to undergo IVF treatment and categorized as expected normal responders) (Ozkan, 2019).
- Patients under thyroid medication.
Exclusion
- Presence or history of endocrine abnormalities (at the exception of patients who are under thyroid medication).
- Abnormal outcome of blood biochemistry or hematology.
- Obese patients with BMI \> 40.
- Couples for whom the male partner has to undergo surgical sperm retrieval.
Key Trial Info
Start Date :
September 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2024
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT05298657
Start Date
September 1 2022
End Date
August 31 2024
Last Update
July 12 2022
Active Locations (1)
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1
ART Fertility Clinic
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates