Status:
RECRUITING
Prediction of Surgical Resectability After FOLFIRINOX Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: the Role of Diffusion Weighted Magnetic Resonance Imaging, Radiomics and Liquid Biopsy (PeRFormanCe Trial)
Lead Sponsor:
University Hospital, Ghent
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this prospective study, new diagnostic tools will be explored for patients with borderline resectable and locally advanced pancreatic ductal adenocarcinoma (BR or LAPDA) who undergo neoadjuvant che...
Detailed Description
Study Aim The aim of this study is to assess whether the combination of radiomics, diffusion-weighted magnetic resonance imaging (DW-MRI), and multi-omics profiling in liquid biopsies-both before and ...
Eligibility Criteria
Inclusion
- Male or female patients, aged 18 years and above
- Diagnosis of BR or LA PDAC according to NCCN guidelines (version 1.2020)
- Histologic diagnosis of PDAC
- No medical or anesthetic contra-indication for surgery
- Able to understand nature of the study procedures
- Willing to participate and give written informed consent
Exclusion
- Age \< 18 years
- Distant metastases
- Histologic diagnosis of cholangiocarcinoma, duodenal carcinoma or neuroendocrine tumor
- Known hypersensitivity for MRI contrast
- Pacemaker or prosthesis with incompatibility for MRI
- Claustrophobia
- Pregnancy or breastfeeding
- Not able to understand nature of the study procedure
- Performance status ECOG score: \>2
Key Trial Info
Start Date :
December 12 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT05298722
Start Date
December 12 2022
End Date
March 1 2028
Last Update
April 2 2025
Active Locations (8)
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1
Ghent University Hospital
Ghent, East Flanders, Belgium, 9000
2
AZ Sint Blasius Dendermonde
Dendermonde, Belgium, 9200
3
AZ Alma Eeklo
Eeklo, Belgium, 9900
4
AZ Jan Palfijn Ghent
Ghent, Belgium, 9000