Status:
UNKNOWN
The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients"
Lead Sponsor:
Sohag University
Conditions:
PCOS
ICSI
Eligibility:
FEMALE
18-35 years
Phase:
EARLY_PHASE1
Brief Summary
To analyze the effect of pretreatment with dydrogesterone vs combined estradiol valerate and dydrogesterone on embryologic parameters, chemical and clinical pregnancy rates of ICSI in women with PCOS.
Detailed Description
Polycystic ovary syndrome (PCOS) is a very common endocrine disorder affecting 5-7% of women in reproductive age. It is the leading cause of anovulatory infertility in this age group. It is characteri...
Eligibility Criteria
Inclusion
- -Women with PCOS undergoing their first cycle of ICSI. PCOS diagnosis will be performed based on Rotterdam criteria (2003) based the presence of oligomenorrhea, polycystic ovaries on ultrasonography (defined as either an ovary that contains ≥ 12 antral follicles or ovarian volume\>10cm3) as well as biochemical or clinical signs of hyperandrogenism, and after exclusion of other causes of hyperandrogenism as Cushing syndrome and CAH and hypothyroidism.
- age 18 to 35 years.
- BMI between 19 and 25 kg/square meter.
- AMH 3.5-6 ng/ml
- fresh or frozen embryo transfer
Exclusion
- -FSH more than 12 IU /L
- AFC- performed on day 3 of the cycle- less than 4
- Existence of hydrosalpinx on ultrasonography
- uterine disorders as that caused by uterine fibroids.
- . All male partners should have normal semen parameters .
- Women with more than 20 oocytes
- Any sign of early onset OHSS
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2023
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT05300841
Start Date
May 1 2022
End Date
May 1 2023
Last Update
April 14 2022
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