Status:
RECRUITING
Exploration of GCase Activity to Identify a Subpopulation Eligible for a Therapeutic Trial in Dementia With Lewy Bodies
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Dementia With Lewy Bodies
Eligibility:
All Genders
50+ years
Brief Summary
This research focuses on the activity of an enzymatic protein: glucocerebrosidase, in dementia with lewy bodies (DLB). Indeed, the mutation of the GBA gene responsible for a decrease in the activity o...
Detailed Description
Population: 118 patients and 118 control subjects Act of research: blood test Objectifs : * Comparison of glucocerebrosidase activity between patients and controls * Search for variants or mutations...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients :
- Male or female aged ≥ 50 years old
- Presence of an accompanying person
- Dementia with lewy bodies according to the revised criteria of Mc Keith 2017
- Inclusion Criteria for controls:
- Male or female aged ≥ 50 years old
- Absence of cognitive impairment and clinical element for a neurodegenerative disease
- Exclusion Criteria for patients:
- Other neurodegenerative disease
- Gaucher disease
- Exclusion Criteria for controls:
- Neurodegenerative disease
- Cognitive impairment of all causes
Exclusion
Key Trial Info
Start Date :
February 17 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
236 Patients enrolled
Trial Details
Trial ID
NCT05304195
Start Date
February 17 2023
End Date
June 1 2026
Last Update
November 20 2025
Active Locations (1)
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1
Centre de neurologie Cognitive
Paris, France, France, 75010