Status:
COMPLETED
NA-AION Risk Factors: New Perspectives
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
Velux Fonden
Fight for Sight
Conditions:
Non-arteritic Ischemic Optic Neuropathy
Optic Disk Drusen
Eligibility:
All Genders
11+ years
Brief Summary
The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION. The risk factors we are focusing on are comorbidities along with...
Detailed Description
Non-arteritic anterior ischemic optic neuropathy (NA-AION) is the most common acute optic neuropathy in the middle-aged and elderly population and can also occur in children and young adults. NA-AION ...
Eligibility Criteria
Inclusion
- Diagnosis of first episode of NA-AION in study eye with symptom onset within 1 month prior
- Subject age: Age \>10
- NA-AION diagnosis requires:
- disc edema seen by site PI or by referring doctor
- visual field defect in the study eye consistent with NA-AION and mean deviation worse than 3.0 dB using the study visual field examination protocol
- relative afferent pupillary defect (unless the fellow eye had previous NA-AION or other optic nerve or retinal disease that is not exclusionary)
Exclusion
- Previous episode of NA-AION in the study eye only
- Intraocular pressure of \>21 mm Hg in the study eye
- Clinical or pathological evidence of giant cell arteritis
- Diseases that may affect the optic nerve: glaucoma, multiple sclerosis, Alzheimer disease, and Parkinson disease. Evidence of optic disc drusen and optic nerve hypoplasia are not exclusion criteria given they are important parts of the study. We will not exclude significant retinal diseases, since they may be related to underlying etiologies giving rise to ODD, such as macular degeneration, retinal dystrophies, but eyes with significant retinal diseases will be analyzed separately.
Key Trial Info
Start Date :
August 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
179 Patients enrolled
Trial Details
Trial ID
NCT05305079
Start Date
August 1 2021
End Date
August 31 2024
Last Update
November 22 2024
Active Locations (20)
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1
Stanford Medicine
Palo Alto, California, United States, 94305
2
UCSF Medical Center
San Francisco, California, United States, 94143
3
University og Colorado
Boulder, Colorado, United States, 80309
4
Massachusetts Eye and Ear
Boston, Massachusetts, United States, 02114