Status:
RECRUITING
Empagliflozin in Acute Heart Failure
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions:
Acute Heart Failure
Chronic Kidney Diseases
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The objective is to study in a prospective, interventional, single arm, cohort study the potential synergistic diuretic effect of empagliflozin, in addition to furosemide, in hypervolemic patients adm...
Eligibility Criteria
Inclusion
- Inclusion Criteria (all have to apply) :
- moderate to advanced CKD, defined as an eGFR \<45 ml/min/1.73m2; The average creatinine values over the last 12 months will be used to calculate baseline eGFR.
- acutely decompensated heart failure, defined as dyspnea at rest or with minimal physical activity, associated with at least one clinical sign of congestion and at least one objective measure of heart failure (pulmonary-capillary wedge pressure \>20 mm Hg or evidence of pulmonary congestion on chest radiography or brain natriuretic peptide (BNP) level ≥400 pg/ml or N-terminal pro-BNP level ≥1000 pg/ml);
- evidence of inadequate response to loop diuretics, defined as a urine output \< 1000 ml/24h or a weight loss \< 1kg /24h. For patients who have not received loop diuretics, a furosemide stress test can be conducted.
- stable hemodynamics, defined as systolic blood pressure \>90 mmHg and/or mean arterial pressure \>65 mmHg in the absence of intravenous norepinephrine or epinephrine in the last 24 hours.
- Exclusion Criteria:
- new use of a non-loop diuretic other than an MRA
- history of type 1 diabetes mellitus
- euglycemic diabetic ketoacidosis
- liver disease defined by serum levels of transaminases or alkaline phosphatase more than three times the upper limit of normal at screening
- known hypersensitivity to SGLT-2 inhibitors
- use within the last 48 h of an SGLT-2 inhibitor or a combined SGLT-1 and SGLT-2 inhibitor
- maintenance dialysis or need for emergent renal replacement therapy
- gastrointestinal surgery or gastrointestinal disorder that could interfere with trial medication absorption
- recurrent severe genital or urinary tract infection
- pregnancy or breastfeeding
- any other clinical condition that would jeopardize patient safety while participating in this trial
- Patients with an acute rise in creatinine levels (acute cardiorenal syndrome) upon presentation will not be excluded.
Exclusion
Key Trial Info
Start Date :
December 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT05305495
Start Date
December 22 2022
End Date
February 1 2027
Last Update
January 8 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Research Institute of the McGill University Health Center
Montreal, Quebec, Canada