Status:
COMPLETED
Plasmodium Falciparum Genomic Intelligence in Mozambique
Lead Sponsor:
Centro de Investigacao em Saude de Manhica
Collaborating Sponsors:
National Malaria Control Program, Mozambique
Malaria Consortium
Conditions:
Malaria,Falciparum
Malaria in Pregnancy
Eligibility:
All Genders
6+ years
Brief Summary
Mozambique is among the ten countries with the highest burden of malaria worldwide, with an estimated 9.3 million cases in 2018, and constitutes a core target for the World Health Organization (WHO) a...
Detailed Description
Genomic data constitutes a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa....
Eligibility Criteria
Inclusion
- A) LOW TRANSMISSION AREAS
- Any age
- Fever (axillary temperature ≥37.5ºC) or history of fever in the preceding 24 hours
- Positive parasitological test for malaria diagnosis via RDT or microscopy OR
- Household contact of someone with fever/history of fever and Pf positive RDT
- Positive parasitological test for malaria diagnosis via RDT OR
- Pregnant women attending first antenatal care visit AND
- Informed, written consent to participate from participant and/or guardian
Exclusion
- Any symptoms of severe malaria
- Negative parasitological test for malaria via RDT or microscopy (except any women at their first ANC visit, who will be recruited before testing for malaria with an RDT)
- Unwilling to provide informed, written consent
- History of antimalarial treatment in the last 14 days
- B) MEDIUM-TO-HIGH TRANSMISSION AREAS
- Inclusion Criteria:
- Children 2-10 years of age
- Fever (axillary temperature ≥37.5ºC) or history of fever in the preceding 24 hours
- Positive parasitological test for malaria diagnosis via RDT or microscopy OR
- Pregnant women attending first antenatal care visit AND
- Informed, written consent to participate from participant and/or guardian
Key Trial Info
Start Date :
October 12 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2024
Estimated Enrollment :
21848 Patients enrolled
Trial Details
Trial ID
NCT05306067
Start Date
October 12 2021
End Date
March 31 2024
Last Update
August 27 2024
Active Locations (1)
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1
Centro de Investigaçao em Saúde de Manhiça
Manhiça, Maputo Province, Mozambique, 1929