Status:
COMPLETED
IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls
Lead Sponsor:
Istanbul University
Conditions:
Periodontitis
Eligibility:
All Genders
18-65 years
Brief Summary
Periodontitis is an inflammatory disease characterized by periodontal tissue destruction caused by bacterial infection. The immune response plays an important role in the progression of periodontitis....
Detailed Description
IL-35 is a next-generation signaling molecule belonging to the IL 12 cytokine family. It is produced by T-regulatory cells (Treg) consisting of the Α chain (p35). Recent studies have shown that IL-35 ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for grade B-C stage III-IV periodontitis group:
- 18-65 years old
- Not having any systemic disease (diseases that do not affect the periodontal status)
- Non-smoker
- Have not received antibiotic treatment and/or used immunosuppressant medication in the last 6 months
- Have not received any periodontal treatment before
- No pregnancy and breastfeeding status
- Not using any medication regularly
- Having at least 20 teeth
- Those with grade B-C stage III-IV periodontal disease according to the 2017 Classification of Periodontal and Peri-implant Diseases and Conditions
- Inclusion Criteria for periodontal healthy group:
- •In patients who applied to Istanbul University Faculty of Dentistry, Department of Periodontology, periodontally healthy individuals who do not meet the above disease criteria, who do not have a history of periodontitis in any way, will be included in the study. Consisted of individuals with clinically healthy gingiva on an intact periodontium who had a BOP score less than 10% and PD≤3mm, showed no attachment loss or radiographic bone loss.
- Exclusion Criteria:
- Those with systemic modifying disease affecting periodontal status
- Smoker
- Have received antibiotic therapy or immunosuppressive therapy in the last 6 months
- Previously received periodontal treatment in the last 6 months
- Pregnancy and breastfeeding status
- Regular use of drugs that will affect systemic health
Exclusion
Key Trial Info
Start Date :
April 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05306860
Start Date
April 15 2022
End Date
June 30 2023
Last Update
March 5 2024
Active Locations (1)
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1
Istanbul University Faculty of Dentistry
Istanbul, Turkey (Türkiye)