Status:
ACTIVE_NOT_RECRUITING
Efficacy of Low-Dose Topical Steroids in Maintaining Remission of Eosinophilic Esophagitis in Children
Lead Sponsor:
Ann & Robert H Lurie Children's Hospital of Chicago
Conditions:
Eosinophilic Esophagitis
Eligibility:
All Genders
1-21 years
Brief Summary
This study evaluates the decrease in steroid dosing for patients who have achieved remission on a full dose of steroids. Once a patient is in remission they will be enrolled in this study if they choo...
Detailed Description
As the disease usually recurs once steroids are discontinued, and there is concern for complications of untreated disease, continuation of steroids is indefinite after induction of remission. The shor...
Eligibility Criteria
Inclusion
- Patients diagnosed with EoE
- Patients less than 21 years of age at enrollment
- Patients who within the past 12 months have demonstrated histologic remission (\<15 eos/hpf as assessed by upper esophagogastroduodenoscopy (EGD) with biopsy ) to the standard induction dose of topical steroids and have remained on this treatment:
- Topical steroid treatment includes only those with previously published results: Swallowed topical fluticasone (i.e. Flovent®), and Swallowed viscous budesonide (i.e. Pulmicort Respules®) mixed with Honey or Splenda®
- Patients who are interested in lowering their dose of topical steroids.
Exclusion
- Patients with EoE who have not demonstrated histologic remission (\<15 eos/hpf) to topical steroids.
- Patients who are unable or unwilling to take topical steroids.
- Patients who have changed the vehicle or carrier (e.g. Splenda®or honey ) used to mix with the actual steroid drug, after demonstrating histologic remission.
Key Trial Info
Start Date :
May 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05309590
Start Date
May 1 2014
End Date
November 1 2025
Last Update
November 27 2024
Active Locations (1)
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1
Ann & Robert H Lurie Childjren's Hospital of Chicago
Chicago, Illinois, United States, 60611