Status:
RECRUITING
Genetic Analysis to Predict the Development of Paget's Disease
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
European Research Council
Conditions:
Paget Disease
Paget Disease of Bone
Eligibility:
All Genders
45+ years
Brief Summary
Paget's disease of the bone (PDB) is a skeletal disorder with a strong genetic component which can be associated with various complications such as pain, bone deformity, arthritis and deafness. Recent...
Detailed Description
Paget's disease of bone (PDB) is a common skeletal disorder characterised by increased bone turnover affecting one or more bones throughout the skeleton. The natural history of PDB is incompletely und...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA CASES
- Family history of PDB affecting first degree relative such as a parent or sibling.
- Not already diagnosed with PDB
- Participant willing and able to consent and comply with the study protocol.
- Age \> 45 at the time of enrolment.
- EXCLUSION CRITERIA CASES
- Unable or unwilling to provide informed consent
- Contraindication to radionuclide bone scan
- Already diagnosed with PDB
- INCLUSION CRITERIA CONTROLS
- Spouse, partner or friend of case
- Not diagnosed with PDB
- No family history of PDB
- Participant willing and able to consent and comply with the study protocol.
- Age \> 45 at the time of enrolment
- EXCLUSION CRITERIA CONTROLS
- • Unable or unwilling to give informed consent
Exclusion
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
950 Patients enrolled
Trial Details
Trial ID
NCT05309954
Start Date
January 1 2022
End Date
June 1 2027
Last Update
December 2 2025
Active Locations (1)
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1
NHS Lothian
Edinburgh, United Kingdom, EH4 2XU