Status:
RECRUITING
Cognitive Processing Therapy (CPT) Memory Support (MS) Study
Lead Sponsor:
Boston University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
VA Boston Healthcare System
Conditions:
PTSD
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The efficacy of psychological interventions for posttraumatic stress disorder (PTSD) is likely limited by the difficulty participants have learning and remembering important therapy content. According...
Eligibility Criteria
Inclusion
- Current diagnosis of PTSD as determined by the Clinician Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
- For potential participants on psychiatric medication, dose must be stable for the past four weeks.
- Veteran status
Exclusion
- Current DSM-5 diagnoses of unstable bipolar disorder, past or present psychosis, or organic mental disorder
- Active suicidal or homicidal ideation with plan or intent
- Current moderate or severe substance use disorder, as defined by DSM-5 \[i.e., at least 4 diagnostic symptoms of Substance use disorder (SUD) present\]
- Prior receipt of CPT or concurrent therapy for PTSD
- Significant cognitive impairment as indicated by a score \<10th percentile on the Montreal Cognitive Assessment
- History of moderate or severe traumatic brain injury (TBI) based on the Ohio State University TBI Identification Method and Veterans Administration/ Department of Defense (VA/DOD) guidelines
- High verbal memory ability, as indicated by a score \>1 standard deviation (SD) above the population mean on the California Verbal Learning Test® Third Edition (CVLT-3) immediate recall task
Key Trial Info
Start Date :
January 4 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05310097
Start Date
January 4 2023
End Date
April 1 2027
Last Update
March 25 2025
Active Locations (1)
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1
VA Boston Healthcare System
Jamaica Plain, Massachusetts, United States, 02130