Status:
ACTIVE_NOT_RECRUITING
An Observational Cohort Study to Obese Patients With Weight Cycling
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Weight Cycling
Obesity
Eligibility:
All Genders
18-50 years
Brief Summary
Medical nutritional weight loss was effective in reducing body weight and waist circumference and improving a range of cardiovascular disease risk factors in obese patients, with an average effective ...
Eligibility Criteria
Inclusion
- Normal weight (18.5 ≤ BMI \< 24 kg/m2) or obese (28 ≤ BMI \< 35 kg/m2);
- Aged 18 to 50 years old;
- Han nationality;
- Able to follow the weight-loss prescription;
- Able to sign consent independently;
- Definition of Weight cycling: Loss weight more than once in the past 3 years, and weight regain exceeds 5% or more of the baseline weight of losing weight.
Exclusion
- Bodyweight has changed more than ±10% in the past year;
- Taking drugs known to affect body weight (orlistat, GLP-1 receptor agonists, etc.);
- Taking drugs known to affect glucolipid metabolism (such as sulfonylureas, biguanides, acarbose, or insulin) have been taken in the past 6 months or at present; Lipid-lowering drugs such as statins, bate, niacin, and ezetimibe; Diuretics, β -blockers and other antihypertensive drugs; Glucocorticoid, thyroid hormone, etc.);
- Women who are currently pregnant or nearly 3 months breastfeeding;
- With serious eating disorders or vigorous exercise to lose weight;
- Hard physical workers;
- History of serious cardiovascular disease;
- Acute, chronic, or active gastrointestinal diseases;
- Serious systemic diseases;
- History of serious mental disorders;
- Cancer or active tumor;
- Secondary obesity or drug obesity patients: including hypothalamic obesity, pituitary obesity, hypercortisolism, and hypogonadism obesity;
- Severe liver dysfunction (ALT, AST, ALP, and TBil \> the upper limit of 2.5 times reference value);
- Chronic kidney disease (eGFR \< 60 mL/min/1.73 m2 or eGFR \< 90 mL/min/1.73 m2 with proteinuria);
- Those who are considered by the researcher to be poor compliance or unable to complete this research well.
Key Trial Info
Start Date :
April 8 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 20 2028
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT05311462
Start Date
April 8 2022
End Date
December 20 2028
Last Update
January 14 2025
Active Locations (1)
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1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100010