Status:
COMPLETED
Effects of PEA-LUT on Frontal Lobe Functions and GABAergic Transmission in Long-Covid Patients
Lead Sponsor:
Department of Neurorehabilitation, Hospital of Vipiteno-Sterzing (BZ) Italy
Collaborating Sponsors:
I.R.C.C.S. Fondazione Santa Lucia
Conditions:
Fatigue
Cognitive Deficit
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The study explore the efficacy of PEA-LUT in patients suffering from neurological symptoms of Long-Covid
Detailed Description
Aim of this study was testing the possible therapeutic effects of an 8-week therapy with PEA-LUT on GABAB-ergic neurotransmission, LTP-like synaptic plasticity, indexed with transient potentiation of ...
Eligibility Criteria
Inclusion
- previous diagnosis of SARS-CoV-2 infection confirmed through detection of virus RNA by polymerase chain reaction (PCR) testing of a nasopharyngeal swab;
- subsequent recovery from infection as defined by two consecutive negative PCR tests separated by at least a day;
- mild form of COVID-19 (symptoms may include fever, cough, sore throat, malaise, myalgia, anorexia, nausea, diarrhoea, anosmia and ageusia) without necessitating hospital admission;
- complaints of cognitive difficulties and/or sense of fatigue, persisting after SARS-CoV-2 infection.
Exclusion
- prior or concurrent diagnosis of neurological, psychiatric, endocrine, metabolic or cardiopulmonary conditions;
- clinical and/or radiological evidence of COVID-19 related pneumonia during the active phase of the disease;
- anaemia;
- current pharmacological treatment with corticosteroids, antihistamines, antihypertensives, diuretics, antidepressants, anxiolytic or hypnotic drugs at the time of study
Key Trial Info
Start Date :
August 16 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2022
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT05311852
Start Date
August 16 2021
End Date
March 15 2022
Last Update
September 26 2022
Active Locations (1)
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1
Hospital of Vipiteno-Sterzing
Sterzing, BZ, Italy, 39049