Status:
UNKNOWN
Assessment on Effects of Tongjiang Granule in Treating Nonerosive Reflux Disease Overlapping Epigastric Pain Syndrome
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Collaborating Sponsors:
First Affiliated Hospital of Heilongjiang Chinese Medicine University
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
Conditions:
Gastroesophageal Reflux
Functional Dysphonia
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
PHASE2
Brief Summary
Overlapping gastrointestinal symptoms of functional gastrointestinal diseases (FGIDs) is an internationally recognized problem in modern medical diagnosis and treatment. Such patients show more physic...
Detailed Description
Overlapping gastrointestinal symptoms of functional gastrointestinal diseases (FGIDs) is an internationally recognized modern medical treatment problem. More than 40.7% of people worldwide suffer from...
Eligibility Criteria
Inclusion
- It meets the diagnostic criteria of nonerosive reflex disease(NERD)and epigastric pain syndrome(EPS)
- It meets the diagnostic criteria of liver-stomach depression-heat syndrome of traditional Chinese medicine
- Age between 18 and 70 years old
- Patients have informed consent and are willing to receive corresponding treatment
Exclusion
- Patients with active peptic ulcer, gastrointestinal hemorrhage, severe dysplasia of gastric mucosa or suspected malignant change, achalasia or postoperative achalasia
- There are other organic diseases of the digestive system (such as acute and chronic pancreatitis, cirrhosis, etc.), or systemic diseases that affect the gastrointestinal motility, such as hyperthyroidism, diabetes mellitus over 10 years, chronic renal insufficiency, spirit (the score of SAS and SDS shows severe anxiety or depression), nervous system diseases, etc
- Patients with severe organ diseases such as heart, liver and kidney (such as ALT, AST more than 2 times of normal value), hematopoietic system diseases and tumors
- HP infection was positive (bacterial culture, histological examination, urea breath test, rapid urease test and fecal antigen test were positive);
- People with a history of gastric / abdominal surgery (excluding appendectomy);
- Pregnant and lactating women;
- People with a history of allergies to all the test drugs
- Subjects who are participating in other clinical trials or have participated in other clinical trials within 4 weeks
- Other situations that reduce the possibility of enrollment or complicate enrollment according to the judgment of the researcher, such as frequent changes in working environment and other situations that are easy to cause loss of follow-up.
Key Trial Info
Start Date :
March 26 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2024
Estimated Enrollment :
228 Patients enrolled
Trial Details
Trial ID
NCT05312463
Start Date
March 26 2022
End Date
October 1 2024
Last Update
April 5 2022
Active Locations (1)
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1
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Beijing, Beijing Municipality, China, 100091