Status:
ACTIVE_NOT_RECRUITING
Inspiratory Effort and Respiratory Mechanics in Spontaneously Breathing Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Matched Control Study
Lead Sponsor:
Roberto Tonelli
Conditions:
Idiopathic Pulmonary Fibrosis
Eligibility:
All Genders
18+ years
Brief Summary
Idiopathic pulmonary fibrosis is a life-threatening lung disease characterized by progressive deterioration of lung function and a median survival time of 3-5 years from diagnosis. The onset of an acu...
Eligibility Criteria
Inclusion
- previously established diagnosis of IPF; occurring acute exacerbation of IPF as defined by an acute, clinically significant respiratory deterioration characterized by evidence of new widespread alveolar abnormality on chest CT scan (12); age \>18 years; presence of ARF with PaO2/FiO2 ratio \<200 mmHg despite HFNC (set with at least 60 L/min and FiO2 higher than 0.6); suitability for a NIV trial according to the attending staff; consent to measure esophageal pressure.
Exclusion
- acute cardiogenic pulmonary edema,
- concomitant hypercapnic respiratory failure (PaCO2 \>45 mmHg) of any etiology,
- neuromuscular disease or chest wall deformities,
- home long-term oxygen therapy,
- intolerance or contraindication to NIV, such as the need for immediate endotracheal intubation
Key Trial Info
Start Date :
August 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05313672
Start Date
August 1 2016
End Date
August 1 2026
Last Update
April 25 2025
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