Status:
COMPLETED
Cardiometabolic Outcomes With Light Exposure During Sleep
Lead Sponsor:
Northwestern University
Conditions:
Light
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study tested the hypothesis that acute exposure to light during nighttime sleep adversely affects cardiometabolic function.
Detailed Description
This study tested the hypothesis that acute exposure to light during sleep adversely affects next morning glucose homeostasis and whether this effect occurs via reduced sleep quality, melatonin suppre...
Eligibility Criteria
Inclusion
- healthy adults
- ages 18-40 years
- habitual sleep duration of 6.5-8.5 hours
- habitual sleep onset of 9:00 pm-1:00 am
Exclusion
- any sleep disorder as assessed by history and screening questionnaires for obstructive sleep apnea (Berlin) and excessive daytime sleepiness (ESS \>12), and by PSG to exclude sleep apnea (apnea hypopnea index ≥ 15), periodic leg movements (movement arousal index ≥ 15), or REM sleep behavior disorder;
- history of a cognitive or neurological disorder;
- history of a major psychiatric disorder, including but not limited to mood/anxiety, eating, and alcohol/substance abuse disorders;
- depressed mood (Beck Depression Inventory II score ≥ 20);
- diabetes or other endocrine disorders;
- any gastrointestinal disease requiring dietary adjustment;
- blindness or significant vision loss;
- any unstable or serious medical conditions;
- current or recent (within the past month) of psychoactive, hypnotic, stimulant or analgesic medications;
- shift work or other types of self-imposed irregular sleep schedules;
- obesity (body mass index \> 30 kg/m2);
- history of habitual smoking (6 or more cigarettes per week) or drinking (7 or more alcoholic beverages per week) or caffeine consumption greater than 300 mg per day;
- current use of light therapy;
- use of any other legal or illicit substance that may affect sleep and/or appetite;
- allergy to heparin.
- Due to the metabolic stress associated with pregnancy and breastfeeding, patients who were pregnant or breastfeeding were also excluded.
Key Trial Info
Start Date :
February 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05317559
Start Date
February 1 2014
End Date
July 1 2018
Last Update
April 8 2022
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