Status:
WITHDRAWN
Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy.
Lead Sponsor:
University of Alberta
Conditions:
Neurotrophic Keratitis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Many diseases can affect corneal nerves. Corneas that lack normal sensation are considered neurotrophic. Neurotrophic corneas are predisposed to persistent epithelial defects, recurrent erosions, and ...
Detailed Description
Purpose: To trial topical insulin drops to promote healing in neurotrophic keratitis that has been refractory to conventional management versus tarsorrhaphy. Hypothesis: Topical insulin might promote...
Eligibility Criteria
Inclusion
- Diagnosis of neurotrophic keratitis with persistent epithelial defect that has been refractory to conventional treatments for at least 2 weeks
- 18 years or older
- Able to provide informed consent
- Failed other conventional treatments for neurotrophic keratitis
- Understanding and accepting of use of topical insulin alone
Exclusion
- Less than 18 years old
- Pregnant or breastfeeding women
- Unable to provide informed consent
- Unable to comply with tests/follow-up
- Lid function abnormalities (e.g., lagophthalmos, entropion, ectropion, or abnormal orbicularis function from cranial nerve 7 palsy or Bell's palsy)
- Patients who require ongoing topical treatment (e.g. topical ganciclovir)
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 18 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT05321251
Start Date
June 1 2022
End Date
October 18 2023
Last Update
February 5 2024
Active Locations (6)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Alberta
Edmonton, Alberta, Canada, T6G 2C8
2
University of British Columbia
Vancouver, British Columbia, Canada
3
Dalhousie University
Halifax, Nova Scotia, Canada
4
Precision Cornea Clinic
Ottawa, Ontario, Canada