Status:
COMPLETED
Ventilation Modalities and Acute Ischemic Stroke
Lead Sponsor:
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions:
Acute Ischemic Stroke
Sleep Apnea, Obstructive
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Acute ischemic stroke is the second leading cause of death and disability, and it is also one of the main reasons for the high cost of health care. The major risk factors for stroke are hypertension, ...
Detailed Description
Study population: Participants with acute ischemic stroke in the intensive care unit of the Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technol...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Clinical diagnosis of acute ischemic stroke and sleep apnea (AHI≥5/hour)
- Definite cerebral infarct lesions on CT and MRI
- National Institutes of Health Stroke Score (NIHSS) baseline score of 2-20
- State of consciousness (Glasgow Coma Score of ≥9)
- Semi-quantitative cough strength score of ≥2.
Exclusion
- Pre-existing obstructive sleep apnea
- Suspected sleep disorders other than sleep apnea (e.g., episodic sleeping sickness)
- Respiratory distress requiring mechanical ventilation
- Oxygen-dependent chronic obstructive pulmonary disease
- Pregnancy
- Intracranial hemorrhage
- Inability to use a nasal mask or mask (e.g., facial trauma)
- Patients who died within 24 h of admission
- History of other neurological disorders such as Parkinson's disease, neuro infection, neuromuscular disease patients
- Hospice care or comfort measures only
- Inability to provide informed consent
- Inability to provide valid information
- Suicidal ideation.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 15 2023
Estimated Enrollment :
195 Patients enrolled
Trial Details
Trial ID
NCT05323266
Start Date
May 1 2022
End Date
February 15 2023
Last Update
March 22 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Wuhan Union Hospital
Wuhan, Hubei, China, 430022