Status:
NOT_YET_RECRUITING
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
Lead Sponsor:
ShangHai Ji Ai Genetics & IVF Institute
Conditions:
Preimplantation Genetic Testing
Progestin-primed Ovarian Stimulation
Eligibility:
FEMALE
20-37 years
Phase:
PHASE3
Brief Summary
This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients wi...
Eligibility Criteria
Inclusion
- Women age between 20 and 37 years.
- Women diagnosed with PCOS according to the modified Rotterdam criteria: oligomenorrhea or amenorrhea, together with the presence of ≥12 antral follicles (≤9 mm) and/or ovarian volume \>10 mL on transvaginal ultrasonographic scanning, and/or clinical/ biochemical hyperandrogenism. Other causes of hyperandrogenism and ovulation dysfunction-including tumours, congenital adrenal hyperplasia, hyperprolactinaemia and thyroid dysfunction-were excluded
Exclusion
- Presence of a functional ovarian cyst with E2\>100 pg/mL
- Endometriosis grade 3 or higher
- Repeated implantation failure (\>=4 embryos replaced or \>=2 blastocysts replaced without success)
- Women with a uterine cavity abnormality, such as a uterine congenital malformation (uterus uni-cornate, bicornate, or duplex); untreated uterine septum, adenomyosis, submucous myoma, or endo-metrial polyp(s)
- Women who are indicated and planned to undergo PGT-SR (Preimplantation genetic testing for structural rearrangement) or PGT-M (Preimplantation genetic testing for monogenic disorder), for example, parental abnormal karyo-type or diagnosed with monogenic disease;
- Recipient of oocyte donation
- Presence of hydrosalpinx which is not surgically treated
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
204 Patients enrolled
Trial Details
Trial ID
NCT05326087
Start Date
December 1 2025
End Date
December 1 2027
Last Update
May 31 2025
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