Status:
RECRUITING
Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment
Lead Sponsor:
RenJi Hospital
Conditions:
Liver Transplantation
Renal Insufficiency, Chronic
Eligibility:
All Genders
18-75 years
Brief Summary
Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impai...
Detailed Description
This is a single-center, prospective, cohort study. This study will include approximate 369 post-liver transplantation patients with renal impairment and have received renal biopsy. Demographic charac...
Eligibility Criteria
Inclusion
- age 18-75 years
- patients received liver transplantation
- new onset of proteinuria(defined as 24-hour proteinuria\>1g/24h, or Urinary albumin creatinine ratio(UACR)\>300mg/g on at least two occasions), and/or renal impairment: eGFR \<60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline
- have received renal biopsy in the past 3 months
- Signed informed consent form(ICF)
Exclusion
- patients received renal transplantation
- hepatic failure
- severe bleeding risk or platelet \<70\*109/L
- chronic kidney insufficiency with eGFR\<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy
- uncontrolled mental disease or unable to cooperate during operation
- Pregnancy or lactation
- not suitable for this study judged by investigaters
Key Trial Info
Start Date :
June 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
369 Patients enrolled
Trial Details
Trial ID
NCT05326399
Start Date
June 1 2022
End Date
December 31 2030
Last Update
November 28 2025
Active Locations (2)
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1
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, 200127
2
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, 200127