Status:
RECRUITING
The Patient Cohort of the National Center for Precision Medicine in Leukemia
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
Brief Summary
If for years the treatment strategy of leukemia and related disorders (LRDs, including acute leukemias and predisposition syndromes) has been based solely on whether the patient could receive or not i...
Eligibility Criteria
Inclusion
- Patient with newly diagnosed previously untreated de novo, secondary or therapy-related leukemia or related disorders (LRD), including AML, ALL, HR-MDS (according to the international score IPSS), and MNP-related myelofibrosis
- Patient informed and not opposed to participating
- Affiliation to social security or any health insurance
Exclusion
- LRD which is not morphologically proven (patients with granulocytic sarcoma may be included)
- Previous treatment for LRD, apart from:
- Hydroxyurea or previous MDS/MPN-CML therapy in AML patients
- Steroids, vincristine, intrathecal prophylactic or curative injection or previous CML therapy in ALL patients
- Erythroid stimulating agents (ESAs), luspatercept, granulocyte colony-stimulating factor (G-CSF), eltrombopag or other TPO agonist, iron chelation therapy, hypomethylating agents (HMAs), lenalidomide or any investigational drug previously used to treat MDS in HR-MDS patients
- Hydroxyurea, standard or pegylated interferon alpha, ruxolitinib or other JAK inhibitors, busulfan, anagrelide, ESAs or any investigational drug previously used to treat MPN in MPN-related myelofibrosis patients
- Patient under guardianship / curatorship
- Patient under AME
- Opposition of the patient to be enrolled in the eTHEMA cohort
Key Trial Info
Start Date :
March 28 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2042
Estimated Enrollment :
3000 Patients enrolled
Trial Details
Trial ID
NCT05326919
Start Date
March 28 2022
End Date
March 1 2042
Last Update
May 29 2024
Active Locations (3)
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1
Hôpital Avicenne
Bobigny, France
2
Hopital Robert Debré
Paris, France
3
Hôpital Saint Louis
Paris, France