Status:
UNKNOWN
Serum Rennin Kinetics Versus Serum Lactate Kinetics as Predictors of Mortality in Septic Shock Patients
Lead Sponsor:
Assiut University
Conditions:
Septic Shock
Eligibility:
All Genders
18-80 years
Brief Summary
Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lac...
Detailed Description
Resuscitation in the ICU was traditionally based on blood pressure (1, 2). An assumption that adequate tissue perfusion cannot be made at pressures of 65 mm Hg, and the number itself has been challeng...
Eligibility Criteria
Inclusion
- age over 18
- anticipated stay \>24 hours
- signed informed consent by patient or next-of-kin.
- Septic shock patients, septic shock was defined as persistent hypotension (defined as the need for vasopressors to maintain mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L\] despite adequate volume resuscitation
Exclusion
- chronic kidney disease stage IV/V (baseline eGFR (estimated glomerular filtration rate) \<30ml/min/1.73m2),
- do not resuscitate order.
Key Trial Info
Start Date :
June 30 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05327881
Start Date
June 30 2022
End Date
December 30 2023
Last Update
April 14 2022
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