Status:
ACTIVE_NOT_RECRUITING
Effect of Different Antihypertensive Drugs on Central Blood Pressure
Lead Sponsor:
Korea University Anam Hospital
Conditions:
Hypertension
Eligibility:
All Genders
19-80 years
Phase:
NA
Brief Summary
Trial name) The differential effects of antihypertensive drugs on central blood pressure: comparison between beta-blocker(BB) and angiotensin receptor blocker ARB) Objectives) To evaluate the effect ...
Detailed Description
1. Study background Different antihypertensive agents induce varied response in terms of CBP, even if peripheral BP-lowering effects are similar. In ASCOT-CAFE study, the atenolol±thiazide group and t...
Eligibility Criteria
Inclusion
- For patients with newly diagnosed hypertension: SBP ≥140mmHg or DBP ≥90 mmHg
- For patients with prior diagnosis of hypertension: SBP ≥140mmHg or DBP ≥90 mmHg after a two-week washout period of previous antihypertensive medications.
- Patients who wrote the informed consent: The subject should be able to receive informations of treatment, risks, effects and other therapeutic modalities regarding different antihypertensive agents at least verbally, and investigators should be provided written informed consent from a subject or a legally recognized representative prior to giving any treatment related to the study.
Exclusion
- Patients with contraindications or hypersensitive/allergic reactions to any class of antihypertensive agents.
- Severe hypertension patients: SBP ≥200mmHg or DBP ≥110 mmHg at any visit during the study.
- Chronic kidney disease (creatinine \>1.5mg/dL)
- Chronic obstructive pulmonary disease
- Chronic heart failrue (LVEF ≤35%)
- Patients who are pregnant or plan on becoming pregnant during the duration of the study, both male and female sex
- Patients who are illiterate, have psychiatric illnesses or who do not agree to be enrolled in the study.
- Other patients who are deemed unfit for the study as assessed by the investigators.
Key Trial Info
Start Date :
January 6 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT05328310
Start Date
January 6 2019
End Date
March 1 2026
Last Update
April 14 2022
Active Locations (1)
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1
Korea University Anam Hospital
Seoul, South Korea