Status:
UNKNOWN
The Comparative Effectiveness Between ARNI and ACE Inhibitor/ARB Medication in Patient With HFrEF
Lead Sponsor:
Wonju Severance Christian Hospital
Conditions:
Heart Failure
Mortality
Eligibility:
All Genders
18+ years
Brief Summary
This study aimed to evaluate the effectiveness, safety, and cost-effectiveness of ARNI and ACEi/ARBs in real-world practice. This study could find out what the unmet medical needs are in real world pr...
Detailed Description
Despite developments and improvements in treatment strategies, heart failure (HF) remains a significant socioeconomic burden and leads to individual health problems due to its high mortality and readm...
Eligibility Criteria
Inclusion
- HF patients were defined as those with "heart failure" according to the disease code in the main code and the sub-code in the claims data.
- HF patients who were assigned the following KCD-6 disease codes were considered as: "hypertensive heart disease with (congestive) HF" (I11.0), "hypertensive heart and renal disease with (congestive) HF" (I13.0), "hypertensive heart and renal disease with both (congestive) HF and renal failure" (I13.2), and "HF" (I50) including "congestive HF" (I50.0), "LV failure" (I50.1), and "HF and unspecified" (I50.9).
- HFrEF patients were defined with the following KCD-6 disease codes: "Congestive heart failure with systolic dysfunction"(I5004), "Left ventricular failure"(I501), "Ischaemic cardiomyopathy"(I22.5), "Dilated cardiomyopathy" (I420).
- Hospitalized heart failure is defined as the HF disease code and admission.
Exclusion
- Less than 18 years old
- In case where investigators determine it's inappropriate to be included in the study as per investigators' clinical judgment
Key Trial Info
Start Date :
February 18 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
1000000 Patients enrolled
Trial Details
Trial ID
NCT05329727
Start Date
February 18 2022
End Date
December 31 2025
Last Update
August 1 2023
Active Locations (1)
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1
Yonsei University Wonju College of Medicine
Wŏnju, Gangwondo, South Korea, 26426