Status:
COMPLETED
Glucocorticoids for Post-operative Patients With Acute Type A Aortic Dissection (The GLAD Trial)
Lead Sponsor:
Shanghai Zhongshan Hospital
Conditions:
Methylprednisolone
Glucocorticoid
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study is designed to evaluate the effects of glucocorticoid(GC) on improving post-operative organ dysfunction in patients with acute type A aortic dissection(aTAAD). Subjects with confirmed diagn...
Eligibility Criteria
Inclusion
- Informed consent
- Age above 18 years old (including 18 years old), regardless of gender;
- Confirmed type A aortic dissection with computer tomography and received surgical intervention
- Life expectancy \> 3 days after surgery
Exclusion
- History of cardiac surgery within the past 3 months or possible iatrogenic aortic dissection
- Bacterial or fungal infection in the past 30 days
- Glucocorticoid or any other anti-inflammatory drug usage in the past 14 days
- Allergic to glucocorticoid
- Pregnant
- Implantation of ICD or permanent pacemaker
- Patients diagnosed with malignant tumor undergoing chemotherapy and immunotherapy.
- Patients with pre-operative severe liver dysfunction (CTP grade C)
- Patients with pre-operative renal insufficiency (patients receiving renal replacement therapy before surgery)
Key Trial Info
Start Date :
February 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 29 2023
Estimated Enrollment :
212 Patients enrolled
Trial Details
Trial ID
NCT05329740
Start Date
February 7 2022
End Date
November 29 2023
Last Update
December 26 2023
Active Locations (1)
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1
Zhongshan Hospital
Shanghai, Shanghai Municipality, China, 200000