Status:
COMPLETED
Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells
Lead Sponsor:
ART Fertility Clinics LLC
Collaborating Sponsors:
Organon and Co
Conditions:
Ovarian Function Insufficiency
Fertility Issues
Eligibility:
FEMALE
18-38 years
Phase:
PHASE1
Brief Summary
To study the influence of different daily rec-FSH dosages (150 IU versus 300 IU), performed in the same patient in consecutive cycles, on the relation between FSH- and LH-receptors of the granulosa ce...
Detailed Description
This is a prospective cross-over study. Investigators want to study the effect of different dosages of recombinant FSH in the same patient on the expression of the FSH- and LH-receptors in the granulo...
Eligibility Criteria
Inclusion
- Desire to perform oocyte freezing for social fertility preservation, age 18 - 38 years
- BMI of 18-32 kg/m2
- Regular menstrual cycles with a length of 24-35 days
- Anti-Muellerian-Hormone levels between 1.3 - 6.25 ng/ml (Ferraretti and Gianaroli, 2014; Calzada et al., 2019)
Exclusion
- Occurrence of ovarian hyperstimulation syndrome (OHSS)
- Occurrence of poor ovarian response (AFC \< 5 and AMH \< 0,5ng/ml) in previous ovarian stimulation treatment (20)
- Polycystic ovary syndrome (PCOS) (21)
Key Trial Info
Start Date :
July 5 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2024
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT05330130
Start Date
July 5 2023
End Date
June 30 2024
Last Update
January 9 2025
Active Locations (1)
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1
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates, 60202