Status:
COMPLETED
Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Shock
Cardiovascular Diseases
Eligibility:
All Genders
18-80 years
Brief Summary
This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
Detailed Description
Post-cardiotomy shock (PCS) occurs in up to 5% of cardiovascular surgeries and has an in-hospital mortality rate as high as 75%. It is unclear if patients with PCS despite achieving standard resuscita...
Eligibility Criteria
Inclusion
- Adult patients (\>18 years old)
- Receiving elective coronary artery bypass graft (CABG)
- Receiving valvular surgery requiring cardiopulmonary bypass
Exclusion
- Unable to tolerate sublingual microcirculatory flow imaging (e.g., non-intubated patients dependent upon oxygen by facemask, poor mouth opening)
- receiving an emergent procedure
- have an actively treated malignancy
- mitochondrial disorder
- receiving surgery requiring deep hypothermic circulatory arrest.
Key Trial Info
Start Date :
September 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2023
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT05330676
Start Date
September 1 2020
End Date
April 1 2023
Last Update
May 2 2024
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104