Status:
TERMINATED
MicroRNA Activation of LOX-1 Mechanisms in Endometriosis
Lead Sponsor:
Penn State University
Conditions:
Endometriosis
Eligibility:
FEMALE
18-45 years
Phase:
PHASE4
Brief Summary
Endometriosis is a disorder that occurs in women. With endometriosis, tissue that should be found in the womb is found in sites outside of the womb. This disorder impairs the function of the cells tha...
Detailed Description
Epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation and cardiovascular (CV) risk. Circulating factors, Low-density lipoprotein (LDL) and o...
Eligibility Criteria
Inclusion
- Women between the ages of 18 and 45 years with endometriosis (diagnosis by prior laparoscopy by subject's own physician \<5 years prior, and reported by the subject to the researchers)
Exclusion
- Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
- Diabetes (HbA1C .6.5%)
- BP\>140/90
- Taking pharmacotherapy that could alter peripheral vascular control (e.g. insulin sensitizing, cardiovascular medications)
- Pregnancy
- Breastfeeding
- Taking illicit and/or recreational drugs
- Abnormal liver function
- Rash, skin disease, disorders of pigmentation, known skin allergies
- Diagnosed or suspected metabolic or cardiovascular disease
- Persistent unexplained elevations of serum transaminases
- Known allergy to latex or investigative substances
Key Trial Info
Start Date :
May 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT05331053
Start Date
May 1 2018
End Date
August 31 2024
Last Update
January 30 2025
Active Locations (1)
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1
The Pennsylvania State University
University Park, Pennsylvania, United States, 16801