Status:
UNKNOWN
Effects of Intraoperative Hemoperfusion on Acute Kidney Injury After Aortic Dissection
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Conditions:
Aortic Dissection
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Acute kidney injury (AKI) is a common and serious complication after aortic dissection (AD), and it is closely related to the inflammatory response associated with cardiopulmonary bypass. Hemoperfusio...
Detailed Description
The aim of this study is to explore the effect of hemoperfusion during cardiopulmonary bypass (CPB) on the expression of CIRP in serum after aortic dissection and the incidence of postoperative acute ...
Eligibility Criteria
Inclusion
- Patients aged from 18 to 75 years old;
- Patients had aortic dissection type A with onset within 7 days.
Exclusion
- Preoperative CTA suggests unilateral or bilateral renal artery false lumen blood supply;
- Past history of renal insufficiency;
- Difficulty in hemostasis during operation due to taking anticoagulant and antiplatelet drugs for various reasons before operation, and the CPB time exceeds 4 hours;
- Severe organ perfusion before surgery, such as lower extremity ischemia or preoperative coma;
- BMI\>40 Kg/m\^2 or pregnancy status.
Key Trial Info
Start Date :
April 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
206 Patients enrolled
Trial Details
Trial ID
NCT05331495
Start Date
April 20 2022
End Date
December 31 2024
Last Update
April 15 2022
Active Locations (1)
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1
First Affiliated Hospital of Xian Jiaotong University
Xi'an, Shaanxi, China, 710061