Status:
COMPLETED
Umbilical Cord-derived Mesenchymal Stem Cell Infusion in the Management of Adult Liver Cirrhosis
Lead Sponsor:
Vinmec Research Institute of Stem Cell and Gene Technology
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
This is a phase I, open label, single arm trial using UC-MSCs to treat patients with liver cirrhosis that includes 20 patients. The primary outcome measure will be change in MELD score at 3, 6, and 12...
Detailed Description
Liver cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands and causes by many forms of liver diseases and conditions such as hepatitis and chronic a...
Eligibility Criteria
Inclusion
- Aged 18 to 70 years old.
- Patients diagnosed of liver cirrhosis: splenomegaly, elevated hepatic enzymes and/or esophageal varices detected by endoscopy, or liver biopsy demonstrated liver cirrhosis
- Be willing to complete the study and sign the consent form.
Exclusion
- Younger than 18 or older than 70 years old
- Recent infection
- Patients with history of chronic diseases such as cancer, chronic hepatitis, chronic kidney disease.
- Any clinically significant blood coagulation disorder(s)
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05331872
Start Date
November 1 2020
End Date
September 30 2023
Last Update
June 4 2024
Active Locations (1)
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1
Vinmec Research Institute of Stem Cell and Gene Technology
Hanoi, Vietnam, 100000