Status:
COMPLETED
Spatial Analysis of Host-parasite Interactions in Cutaneous Leishmaniasis in Ethiopia
Lead Sponsor:
Institute of Tropical Medicine, Belgium
Collaborating Sponsors:
University of Gondar
University of York
Conditions:
Cutaneous Leishmaniases
Eligibility:
All Genders
12-50 years
Brief Summary
Cutaneous leishmaniasis manifestations range from self-healing localized skin ulcers/nodules to diffusely spread chronic lesions. Knowledge on the host-parasite interactions underpinning the different...
Detailed Description
Specific objectives: 1. To profile the full heterogeneity in skin and lesion immunity (single cell RNAseq), and the cellular microenvironment surrounding infected and non-infected macrophages (digita...
Eligibility Criteria
Inclusion
- Willing and able to provide informed consent
- Clinically confirmed CL diagnosis
- Between 12 and 50 years of age
Exclusion
- Difficult or too painful sampling zone (see skin biopsy procedure below)
- (Primary) lesion size \< 1 cm
- Already receiving CL treatment or received CL treatment in the last 3 months (excluding traditional medicine)
- Known major comorbidity at time of diagnosis (e.g. VL, HIV, TB, malaria, severe intestinal helminth infection)
- Medical history of VL
- Severely underweight (BMI\<16)
- Known pregnancy
- Use of immunosuppressive medication in the last month
- Known excessive alcohol use (between \>10 intakes/day and \>10 intakes/week)
- History of hypersensitivity to local anaesthetics
- Presence of keloids/hypertrophic scars
Key Trial Info
Start Date :
March 21 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT05332093
Start Date
March 21 2022
End Date
December 31 2024
Last Update
January 9 2025
Active Locations (1)
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1
University of Gondar
Gonder, Amhara, Ethiopia, 6200