Status:
RECRUITING
Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Helicobacter Pylori Infection
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
The prevalence of H. pylori antibiotic resistance has reached an alarming level worldwide. Antibiotic stewardship programs should be urgently developed and implemented. However, H. pylori antimicrobia...
Detailed Description
This prospective multicenter randomized comparative study will be conducted at the National Taiwan University Hospital, NTUH Bei-Hu Branch, NTUH Hsin-Chu Branch, Taipei City Hospital Renai Branch, Bud...
Eligibility Criteria
Inclusion
- Patients, aged \>= 20, having H. pylori-positive chronic gastritis with/without peptic ulcers (duodenal or gastric ulcers) will be recruited. If the patients failed anti-H. pylori therapy previously, they will be invited to enter this study for evaluating the efficacy of these rescue regimens.
Exclusion
- pregnant or nursing woman;
- serious concomitant illness and malignant tumor of any kind;
- history of hypersensitivity to test drugs；
- serious bleeding during the course of this ulcer;
- previous gastric surgery;
- receiving bismuth salts, PPIs, or antibiotics in the previous month.
Key Trial Info
Start Date :
April 11 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
450 Patients enrolled
Trial Details
Trial ID
NCT05332444
Start Date
April 11 2022
End Date
December 1 2025
Last Update
September 23 2025
Active Locations (1)
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1
National Taiwan University Hospital
Taipei, Taiwan