Status:

RECRUITING

The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation

Lead Sponsor:

National Taiwan University Hospital

Conditions:

Atrial Fibrillation

Eligibility:

All Genders

20+ years

Phase:

NA

Brief Summary

This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).

Detailed Description

Rate control therapy is the first-line treatment for atrial fibrillation (AF). Resting heart rate(HR) is the treatment target of rate control therapy in current clinical practice; However, the optimal...

Eligibility Criteria

Inclusion

  • \> 20 years of age.
  • Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months.
  • Resting heart rate \< 80 bpm.
  • Left ventricular ejection fraction \> 50%.

Exclusion

  • Beta-blocker usage due to indications other than rate control for atrial fibrillation.
  • Inability to perform a cardiopulmonary exercise testing.
  • Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription.
  • Patients with implantable cardioverter defibrillator or pacemaker.
  • Pregnancy.
  • Inability to provide informed consent.

Key Trial Info

Start Date :

July 1 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2025

Estimated Enrollment :

40 Patients enrolled

Trial Details

Trial ID

NCT05332457

Start Date

July 1 2025

End Date

December 31 2025

Last Update

March 24 2025

Active Locations (1)

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1

National Taiwan University Hospital

Taipei, Taiwan, 100