Status:
UNKNOWN
Incidence of cCPHD in Denmark - a National Observational Study
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
Rigshospitalet, Denmark
Aalborg University Hospital
Conditions:
Combined Pituitary Hormone Deficiency Genetic Form
Combined Pituitary Hormone Deficiency
Eligibility:
All Genders
1-25 years
Brief Summary
The pituitary gland is a small pea-sized gland that produces a variety of important hormones. Some children are born with a deficient production of two or more pituitary hormones. This rare and potent...
Detailed Description
1. Background Congenital combined pituitary hormone deficiency (cCPHD) is defined as the partial or complete loss of more than one hormone secreted from the pituitary gland, caused by genetic or p...
Eligibility Criteria
Inclusion
- Born between January 1, 1996, and December 31, 2020.
- Registered in Danish National Patient Registry or locally at Hans Christian Andersen Children´s Hospital, Odense University Hospital, Department of Growth and Reproduction, Rigshospitalet, Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital or Department of Pediatrics, Aalborg University Hospital with an ICD-10 diagnosis code E23·0-E23·9 (hypofunction and other disorders of pituitary) and/or Q89·2G (congenital malformation of pituitary) before age 15 years.
- Validated secondary/tertiary deficiency of two pituitary hormones before age 18 years.
Exclusion
- ICD-10 diagnosis codes indicating acquired PHD.
- No available hospital files.
- Less than two documented secondary/tertiary hormone deficiencies.
- Acquired CPHD.
Key Trial Info
Start Date :
February 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2022
Estimated Enrollment :
127 Patients enrolled
Trial Details
Trial ID
NCT05334563
Start Date
February 1 2021
End Date
August 1 2022
Last Update
July 7 2022
Active Locations (1)
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1
HCA Research, Odense University Hospital
Odense, Denmark, 5000