Status:
RECRUITING
Brain Circuitry Changes in Central Poststroke Pain: a Clinical and Neuroimaging Study
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
CPP
Pain
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Central poststroke pain (CPP) is estimated to affect up to 10% of stroke patients and is one of the most difficult-to-treat conditions with a detrimental effect on patient's quality of life. So far, n...
Detailed Description
Central poststroke pain (CPP) is estimated to affect up to 10% of stroke patients and is one of the most difficult-to-treat conditions with a detrimental effect on patient's quality of life. So far, n...
Eligibility Criteria
Inclusion
- Inclusion Criteria patients:
- Patients with a haemorrhagic or ischemic stroke affecting the somatosensory system as defined by both CT or MRI and clinical criteria
- Patient age between 18-75 years
- Signed written informed consent
- Exclusion Criteria patients:
- Secondary stroke due to a cerebral vascular malformation or tumor
- Patients with aphasic syndromes and impaired verbal communication, complete sensory-motor hemi-neglect and restrictions of the ability to report on their pain and cooperate during sensory testing
- Patients with severe stroke NIHSS \> 14 and or Modified Rankin Scale (MRS) \> 3
- History of severe myelopathy or polyneuropathy with clinical sensory deficits and history of neuropathic pain
- Widespread stroke size due to internal carotid artery-occlusion or more than one main territory (anterior, middle or posterior cerebral artery)
- Contraindication for 7T MRI (metallic implant, tattoo, claustrophobia, etc.)
- In case of women \< 45 years of age: pregnancy
- Inclusion Criteria for healthy volunteers
- Informed consent as documented by signature
- Age: ≥18 years and ≤ 75 years
- Exclusion criteria for healthy volunteers
- Pregnancy and breastfeeding
- Contraindication for 7T MRI (metallic implant, tattoo, claustrophobia, etc.)
Exclusion
Key Trial Info
Start Date :
July 18 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT05335668
Start Date
July 18 2022
End Date
September 1 2025
Last Update
October 17 2024
Active Locations (1)
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1
Dep. of Neurosurgery, Bern University Hospital
Bern, Switzerland, 3000