Status:
RECRUITING
Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections
Lead Sponsor:
Helsinki University Central Hospital
Collaborating Sponsors:
University of Turku
Tampere University Hospital
Conditions:
Infection Post Op
Hysterectomy
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%. By reducing p...
Eligibility Criteria
Inclusion
- Women undergoing hysterectomy for benign indication in University Hospitals (Helsinki University Hospital, Turku University Hospital, Tampere University Hospital, Oulu University Hospital and Kuopio University Hospital) who have not any contraindications for azithromycin or cefuroxime.
Exclusion
- Inability to understand the study protocol.
- Allergy for either cefuroxime or azithromycin.
- Congenital or acquired prolonged Q-T-corrected interval. All the participants will be asked about arrhythmias and whether they have congenital arrhythmias in the family,
- Electrocardiogram will be checked for all the participants.
- Use of medicines that may prolong Q-T-corrected interval (class Ia arrhythmia medications, quinidine, procainamide, and class III arrhythmia medications dofetilide, amiodarone and sotalol).
- Use of selective serotonin reuptake inhibitor medication and prolonged Q-T-corrected interval.
Key Trial Info
Start Date :
September 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
2278 Patients enrolled
Trial Details
Trial ID
NCT05337566
Start Date
September 5 2022
End Date
December 1 2030
Last Update
August 21 2024
Active Locations (6)
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1
Helsinki University Central Hospital
Helsinki, Finland
2
Jyväskylä Central Hospital
Jyväskylä, Finland, 40620
3
Kuopio University Central Hospital
Kuopio, Finland, 70029
4
Oulu University Central Hospital
Oulu, Finland, PL23