Status:
RECRUITING
Sensitivity of Repetitive Nerve Stimulation Performed in the Evening vs in the Morning in Myasthenia Gravis
Lead Sponsor:
Jagiellonian University
Conditions:
Myasthenia Gravis
Eligibility:
All Genders
18-80 years
Brief Summary
Myasthenia gravis (MG) is the autoimmune disorder affecting the neuromuscular junction, characterized by fatigue, which increases gradually through the day. The repetitive nerve stimulation (RNS) rema...
Detailed Description
Myasthenia gravis (MG) is the autoimmune disorder affecting the neuromuscular junction with morbidity estimated at 70-320 per 1 000 000. The main symptom is the fatigue, which increases gradually thro...
Eligibility Criteria
Inclusion
- Patients with suspected or diagnosed myasthenia gravis (ocular and generalized form)
- Patients with performed or planned determination of anti-AChrR and anti-MUSK antibodies.
- Disease severity of at least 1 in the classification of the severity of myasthenia gravis according to the recommendations of the Myasthenia Gravis Foundation of America
Exclusion
- respiratory failure
- severe bulbar symptoms
- pharmacotherapy with substances that may worsen neuromuscular transmission disorders
- current infection
- coexisting diseases of the peripheral nervous system which may affect the result of the fatigue test, e.g. polyneuropathy or myopathy
- cognitive and behavioral disorders that may negatively affect patient's adherence to study protocol
- Medication with steroids due to myasthenia
- Severity of myasthenia that makes the discontinuation of acetylcholinesterase inhibitors unsafe.
Key Trial Info
Start Date :
June 3 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05337891
Start Date
June 3 2022
End Date
September 1 2026
Last Update
October 10 2024
Active Locations (1)
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1
Jagiellonian University Medical College, Department of Neurology
Krakow, Lesser Poland Voivodeship, Poland, 31503