Status:
COMPLETED
The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty
Lead Sponsor:
Hospital for Special Surgery, New York
Conditions:
Anesthesia
Eligibility:
All Genders
40-80 years
Brief Summary
The current study investigates the effect of hypotensive anesthesia on patient hemoglobin levels during primary total knee arthroplasty. Considering that because of the tourniquet there is no blood lo...
Detailed Description
The specific aim of this prospective study is to collect serial hemoglobin levels intraoperatively during hypotensive anesthesia to evaluate if intraoperative intravenous fluid substitution will chang...
Eligibility Criteria
Inclusion
- Non- inflammatory degenerative joint disease of the knee
- Patients scheduled for unilateral primary total Knee arthroplasty
- Age between 40 and 80 years
- Hypotensive spinal-epidural anesthesia with systolic BP \< 95 and diastolic BP \< 65.
- Adequate intraoperative fluid loading: a minimum of 1500 ml IV fluids should be infused during procedure: at least 300 cc/15 minutes.
Exclusion
- Blood coagulopathies resulting in a hypocoagulable state (hemophilia, von Willebrand disease, etc.)
- Blood coagulopathies resulting in a hypercoagulable state (factor V leiden, antithrombin III deficiency, protein C deficiency, protein S deficiency)
- Patients on anti-coagulants (coumadin, plavix, pradaxa, heparin)
- Congestive Heart Failure (at least one medication to treat congestive heart failure)
- Coronary artery disease (s/p bypass, stent or AMI)
- Kidney insufficiency (creatinine \> 1.5)
- Aortic or mitral valve disease
- Pulmonary hypertension
- Revision Knee Surgery
- Inadequate intravenous fluid substitution during the procedure 1.5L during 60 minutes.
Key Trial Info
Start Date :
January 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT05340751
Start Date
January 1 2014
End Date
September 1 2014
Last Update
January 26 2023
Active Locations (1)
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1
Hospital for Special Surgery
New York, New York, United States, 10021