Status:
COMPLETED
The Effect of Acute Intermittent Hypoxia on Motor Learning
Lead Sponsor:
University of Colorado, Boulder
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
University of Colorado, Denver
Conditions:
Incomplete Spinal Cord Injury
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spin...
Eligibility Criteria
Inclusion
- 18 to 70 years old (the latter to reduce likelihood of heart disease);
- Medically stable with medical clearance from physician to participate;
- Motor-incomplete spinal cord injuries at or below C2 and at or above L5;
- AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.);
- More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery;
- Ability to advance one step overground with or without assistive devices;
Exclusion
- Severe concurrent illness or pain;
- Recurrent autonomic dysreflexia;
- History of cardiovascular/pulmonary complications;
- Concurrent physical therapy;
- Pregnant at time of enrollment or planning to become pregnant;
- Untreated painful musculoskeletal dysfunction, fracture or pressure sore;
- History of seizures or epilepsy;
- Recurring headaches;
- Concussion within the last six months;
- Depression or manic disorders
- Metal implants in the head, or pacemaker.
Key Trial Info
Start Date :
May 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 24 2025
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT05341466
Start Date
May 27 2022
End Date
February 24 2025
Last Update
May 14 2025
Active Locations (2)
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1
University of Colorado, Anschutz Medical Campus
Aurora, Colorado, United States, 80045
2
University of Colorado
Boulder, Colorado, United States, 80309