Status:
COMPLETED
Sertraline Effect in Uremic Pruritis
Lead Sponsor:
Alexandria University
Conditions:
Uremic Pruritis
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
This study aims to assess the effect of sertraline on uremic pruritis in patients undergoing regular haemodialysis.
Detailed Description
The reported prevalence of uremic pruritus in adult hemodialysis patients has varied over the years, and some studies suggest the prevalence may be decreasing with more effective dialysis. One of the ...
Eligibility Criteria
Inclusion
- ≥1 month of maintenance haemodialysis, 3 times per week for 4 hours.
- Adult patients with ages between 18-80 years.
Exclusion
- Primary skin diseases (eczema, psoriasis, allergic dermatitis or drug rash).
- Peripheral neuropathy, thyroid disease, leukemia, lymphoma, liver disease, Systemic lupus erythematosus or pregnancy.
- Patients who consumed emollients cream, antihistamine, opioid antagonist, immunosuppressants, cholestyramine, corticosteroids or UVB phototherapy 1 month before study.
- calcium X phosphorus (Ca X P) \>55.0 mg/dl, P \>5.5 mg/dl, parathyroid hormone (PTH) \>450 pg/ml.
- Selective serotonin reuptake inhibitors intolerance.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05341843
Start Date
May 1 2022
End Date
October 1 2022
Last Update
December 14 2022
Active Locations (1)
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1
Faculty of Medicine, Aexandria University
Alexandria, Egypt, 21526