Status:
COMPLETED
The Effect of Nitrate on Brown Fat
Lead Sponsor:
Bournemouth University
Collaborating Sponsors:
University of Portsmouth
Institute of Bioengineering and Bioimaging (IBB)
Conditions:
Diabetes Mellitus, Type 2
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Type 2 diabetes mellitus (T2DM) is a metabolic condition characterized by chronic hyperglycemia and progressive insulin resistance, which progressively lead to macro- and microvascular damage. With th...
Detailed Description
Dietary inorganic nitrate is converted in a reversible, stepwise reaction to nitrite via bacteria on the dorsum of the tongue. Subsequently, small quantities of NO• are produced in the stomach. The re...
Eligibility Criteria
Inclusion
- Males or women with Type 2 Diabetes Mellitus
Exclusion
- Individuals with a BMI over 30
- Individuals with severe claustrophobia (this would make imaging the BAT less reliable)
- Current smokers (or those that have smoked within 3 months)
- Proton pump inhibitors or phosphodiesterase inhibitor users, as these may affect \[cGMP\]. Half life of this drug is short. Participants can choose to not use this if they wish to participate.
- Individuals with any other serious medical condition which would interfere with data interpretation or safety will be excluded from participation.
- Unable to give informed consent
Key Trial Info
Start Date :
June 30 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2023
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT05342012
Start Date
June 30 2022
End Date
July 31 2023
Last Update
October 10 2023
Active Locations (4)
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1
Bournemouth University
Bournemouth, Dorset, United Kingdom, BH12 5BB
2
University of Portsmouth
Portsmouth, Hampshire, United Kingdom, PO1 2UP
3
Southern Health NHS Foundation Trust
Southampton, Hampshire, United Kingdom, SO40 8DX
4
Shore Medical
Poole, United Kingdom