Status:
COMPLETED
Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron
Lead Sponsor:
Tanta University
Conditions:
Delayed Gastric Emptying
Eligibility:
All Genders
25-75 years
Phase:
PHASE2
Brief Summary
One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead...
Detailed Description
It has been shown that delayed gastric emptying and high GRV in critically ill patients are associated with increased mortality in these patients. Different kinds of drugs including metoclopramide, er...
Eligibility Criteria
Inclusion
- Mechanically ventilated ICU patients
- With nasogastric tube feeding
- Gastric Residual Volume \>120 mL (3hours after the last gavage)
Exclusion
- History of diabetes
- Heart block
- Bradycardia (heart rate \<60/min)
- Systolic blood pressure less than 90 mm Hg
- Renal insufficiency
- Using any prokinetic agents such as erythromycin or cisapride within 8 hours before study initiation
- Recent surgery (10 days or less) on the stomach or digestive system
- pregnancy and lactation
- Occurrence of extrapyramidal side effects
- Gastrointestinal (GI) bleeding
Key Trial Info
Start Date :
April 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 17 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05342818
Start Date
April 15 2022
End Date
October 17 2022
Last Update
October 20 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Sharurah Armed Forces Hospital
Sharurah, Saudi Arabia, 000000