Status:
RECRUITING
Optimizing Pulsatility During Cardiopulmonary Bypass
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Endothelial Dysfunction
Acute Kidney Injury
Eligibility:
All Genders
50-70 years
Brief Summary
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or n...
Detailed Description
Cardiac surgery is a high-risk elective surgical procedure frequently requiring CPB in which a machine pumps blood while the surgeon operates on the heart. CPB contributes to surgical risk by causing ...
Eligibility Criteria
Inclusion
- Age 50 to 70
- Able to provide informed consent
- Scheduled for elective cardiac surgery with cardiopulmonary bypass
Exclusion
- Patients undergoing emergency procedures
- Diagnosed with sepsis
- Experiencing delirium
- Experiencing hemodynamic instability (heart rate \> 100 and systolic blood pressure \< 90)
- Patients with a mechanical circulatory support device
- Requiring vasoactive medications before surgery
- Patients with a reduced left ventricular ejection fraction (less than 50%)
- Patients with a contraindication to transesophageal echocardiography
Key Trial Info
Start Date :
July 5 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2025
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT05344573
Start Date
July 5 2022
End Date
July 1 2025
Last Update
November 21 2024
Active Locations (1)
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1
University of Colorado Hospital
Aurora, Colorado, United States, 80045