Status:
RECRUITING
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
Lead Sponsor:
Mount Sinai Hospital, Canada
Collaborating Sponsors:
Sunnybrook Health Sciences Centre
The Hospital for Sick Children
Conditions:
Late-Onset Neonatal Sepsis
Extreme Prematurity
Eligibility:
All Genders
21-32 years
Brief Summary
Fluid-unresponsive hypotension needing cardiotropic drug treatment is a serious complication in very preterm neonates with suspected late-onset sepsis (LOS; defined as culture positive or negative blo...
Detailed Description
In this study, we will use real world data (RWD; defined as data generated during routine clinical practice) collected by our national Canadian Neonatal Network (CNN), which will be further expanded f...
Eligibility Criteria
Inclusion
- ≤32 weeks gestational age and \> 48 hours of life
- Receiving primary vasopressor therapy with Dopamine or Norepinephrine in the context of suspected late-onset sepsis or necrotizing enterocolitis with systemic hypotension (defined as: culture positive or negative bloodstream infection)
Exclusion
- Known chromosomal or genetic anomalies
- Receiving primary therapy with agents other than Dopamine or Norepinephrine
Key Trial Info
Start Date :
February 6 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
550 Patients enrolled
Trial Details
Trial ID
NCT05347238
Start Date
February 6 2023
End Date
March 31 2027
Last Update
July 8 2025
Active Locations (23)
Enter a location and click search to find clinical trials sorted by distance.
1
Banner-University Medical Center Phoenix
Phoenix, Arizona, United States, 85006
2
Dayton Children's Hospital
Dayton, Ohio, United States, 45404
3
Methodist Healthcare
San Antonio, Texas, United States, 78229
4
Foothill's Medical Centre
Calgary, Alberta, Canada