Status:
COMPLETED
Menstrual Cycle Phase and Oral Contraceptive Pill (OCP) Use on Muscle Protein Synthesis
Lead Sponsor:
McMaster University
Collaborating Sponsors:
Natural Science and Engineering Research Council of Canada (NSERC)
Conditions:
Menstrual Cycle
Resistance Exercise
Eligibility:
FEMALE
18-30 years
Phase:
NA
Brief Summary
Skeletal muscle size and function is regulated by various factors, including hormones. While we understand the role of male sex hormones (testosterone), we aren't sure how female sex hormones (estroge...
Eligibility Criteria
Inclusion
- Healthy females, between the ages of 18 and 30 y with a regular menstrual cycle
- Body Mass Index between 18.5 and 30.0 kg/m2
- Able and willing to provide informed consent
Exclusion
- A history of neuromuscular disorders or muscle/bone wasting diseases
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin-dependent or insulin-independent diabetes, or the presence of any other metabolic disease - all of which will be determined via a medical history screening questionnaire
- The use of any medications known to affect protein metabolism (glucocorticoids, non-steroidal anti-inflammatory medication, or prescription strength acne medication, etc.)
- A (family) history of thrombosis
- The use of anticoagulant medications
- Consumption of tobacco-containing products
- Excessive alcohol consumption (\>21 units/wk)
- History of bleeding diathesis, platelet or coagulation disorders
- Currently pregnant
- Irregular menstrual cycle as defined in the study protocol
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05347667
Start Date
May 1 2022
End Date
April 30 2024
Last Update
January 1 2025
Active Locations (1)
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1
Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario, Canada, L8S 4K1