Status:
COMPLETED
Investigation of MDR1 Gene Polymorphism and Losartan Plasma Concentration in Patients Undergoing Hypertensive Episodes While Under Losartan Treatment
Lead Sponsor:
Pamukkale University
Collaborating Sponsors:
Gazi University
Conditions:
Hypertension
Eligibility:
All Genders
18+ years
Brief Summary
Losartan is an antihypertensive drug belonging to the ARB family. It is characterized as the substrate of the Multi Drug Resistance-1 (MDR1) drug-efflux protein (a pump that ensures the removal of dru...
Detailed Description
This trial was conducted in the emergency services of Gazi University and Pamukkale University. The patient group was comprised of 50 individuals presenting with a hypertensive episode (patients under...
Eligibility Criteria
Inclusion
- gave their informed consent
- received minimum 25 mg losartan daily for at least six weeks
Exclusion
- refusal to participate in the study
- illiteracy
- pregnant or in lactation period
- hemodynamically unstable (mean arterial pressure \<65mmHg)
- kidney transplantation
- liver failure (CHILD PUGH Class C and higher patients) or renal failure (GFR\<60)
- taking anti-hypertensive drugs other than losartan
Key Trial Info
Start Date :
October 23 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 15 2019
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05349825
Start Date
October 23 2017
End Date
January 15 2019
Last Update
April 27 2022
Active Locations (1)
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1
Gazi University
Ankara, Turkey (Türkiye), 06560